A world first from Mercedes-Benz, Pre-Safe is an award-winning safety system that triggers enhanced protection if an accident is deemed imminent. It has been standard on all CLS-Class models since June 2006.

Sensors fitted to the vehicle for the Brake Assist system (BAS) and Electronic Stability Programme (ESP) are utilised to detect potential danger, and the following measures are taken in the moments preceding an accident:

- Electric windows and the electric sunroof are closed leaving a small gap

- Seat belts are tightened

- The front passenger seat is moved into a position that offers the best protection (only in conjunction with memory seats - standard equipment on all CLS models)